This gives me one idea that comes to mind at first: Mage styled playthrough. This run with potions only is possible excluding the bosses if you do a pacifist run until you beat the blazes, where now you have weapons available that can deal some great damage. The bosses are not affected by potion effects, so the run ends there, but that is a big leap to a magic play through. The reason bundles are insanely important for such an attempt, is because if the can hold non-stackable items in a stack, you could have a bundle filled with harming potions, open it and you will get what you need, and continue.
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