Potion Expansion: Failure

Potion making has always been fairly stale as there is not much that can happen outside of the set formula for the potions. One way I could see potion brewing being expanded on is by making it so that certain things can go wrong while making a potion at random, such as the potion suddenly becoming an awkward potion, and would require the player to respond to that by using a specific item that would allow it to go back to brew-able state.